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Clinical Trial Considerations: Vertebral Augmentation Devices to Treat Spinal Insufficiency Fractures - Guidance for Industry and FDA Staff

FinalCenter for Devices and Radiological Health10/23/2004

Description

The information collection provisions in this guidance have been approved under OMB control number 0910-0120. This approval expires 5/31/07 . An agency may not conduct or sponsor, and a person is not required to respond to, a collection of information unless it displays a currently valid OMB number.

Scope & Applicability

Product Classes

5
Class II medical device

Biological indicators are regulated as class II medical devices

Vertebral Augmentation Devices

Guidance for devices to treat spinal insufficiency fractures

Phacofragmentation System device

AC powered device with a fragmenting needle intended for use in cataract surgery; specific device subject to these labeling and sterilization requirements

Combination Product

Products combining drug, device, or biological constituents; Generally recommended for Enhanced Documentation; Requires 14971-based framework incorporating ICH Q9; A drug-device combination where the device constituent part detects ingestion.

Class II

The devices that are the subject of this guidance are Class II non-spinal metallic bone screws and washers

Stakeholders

3
Ophthalmic Devices Panel

The appropriate panel is the Ophthalmic Devices Panel

User

Includes patients, healthcare providers, specialized professionals, and consumers.; Includes patients, healthcare providers, specialized professionals, lay users, consumers

Physician

Allowed value for reporter qualification

Regulatory Context

Attributes

5
ultrasonic frequency

oscillated longitudinally at an ultrasonic frequency of about 40,000 hertz

Technological Features

Comparability factor against predicate device

Intended Use

Evidence of a new intended use based on communications

Sterility assurance level

support the use of the proposed cycle and the desired sterility assurance level

substantial equivalence

The standard for clearing a 510(k) device relative to a predicate.

Identified Hazards

Hazards

3
adverse thermal tissue effects

preclude adverse thermal tissue effects from heat generated by oscillation

Device Related Risks

Risks that must be delineated in labeling

collapse of the anterior chamber

preclude excessive vacuum build up which could cause collapse of the eye chamber

Related CFR Sections (4)

See Also (8)