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Bundling Multiple Devices or Multiple Indications in a Single Submission: Guidance for Industry and FDA Staff

FinalCenter for Devices and Radiological Health Center for Biologics Evaluation and Research06/22/2007

Description

The Medical Device User Fee and Modernization Act of 2002 (MDUFMA), P.L. 107-250, amended the Federal Food, Drug, and Cosmetic Act (the act) by authorizing FDA to collect user fees for certain premarket submissions received on or after October 1, 2002. A letter from the Secretary of Health and Human Services to Congress that accompanies the user fee legislation sets forth performance goals and policy and procedural provisions. One of these provisions is entitled, “Bundling Policy,” and states that FDA will consider, in consultation with its stakeholders, when bundling multiple devices in a single submission may be appropriate.

Scope & Applicability

Product Classes

6
In vitro diagnostic devices

IVDs mentioned regarding clinical decision-making impact

Reprocessed single-use devices

SUDs mentioned in the context of bundling submissions; MDUFMA provides new regulatory requirements for reprocessed SUDs.

Combination Products

Products explicitly excluded from the scope of this guidance

Class I Device

Low risk medical devices

Class II Device

Devices subject to section 522 postmarket surveillance orders; devices subject to postmarket surveillance orders

Class III Device

Generally recommended for Enhanced Documentation; Regulatory classification mentioned for implantable sensors and HPV tests; Mentioned in the context of an in vitro nucleic acid test for CMV DNA.

Stakeholders

3
applicant

entity submitting marketing applications

Original equipment manufacturers

Designs of SUDs may be unique to different OEMs.

Branch Chief

FDA contact for modular review steps

Regulatory Context

Attributes

1
User Fee

Fees required for the review of certain premarket submissions.

Related CFR Sections (4)

See Also (8)

Bundling Multiple Devices or Multiple Indications in a Single Submission: Guidance for Industry and FDA Staff | Guideline Explorer | BioRegHub