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Guidance for the Preparation of a Premarket Notification Application for a Surgical Mesh - Guidance for Industry and/or for FDA Reviewers/Staff and/or Compliance

FinalCenter for Devices and Radiological Health03/01/1999

Description

Comments and suggestions may be submitted at any time for Agency consideration to Plastic and Reconstructive Surgery Branch, HFZ-410, 9200 Corporate Boulevard, Rockville, MD 20850. Comments may not be acted upon by the Agency until the document is next revised or updated. For questions regarding the use or interpretation of this guidance contact Charles N. Durfor, Ph.D. at 301-796-6438 or by electronic mail atcharles.durfor@fda.hhs.gov.

Scope & Applicability

Product Classes

3
Biodegradable devices

Devices requiring documentation of product resorption rates.

Polymeric Surgical Mesh

79 FTL for general surgical uses

Surgical Mesh

general surgical uses such as implantation to reinforce soft tissue; The primary device subject to this guidance document.

Stakeholders

2
Sponsor

Entity responsible for submitting applications under section 524B

manufacturer

Entity required to conduct postmarket surveillance; entity responsible for submitting postmarket surveillance plans; Entity holding the approved PMA, HDE, or cleared 510(k); The entity responsible for conducting postmarket surveillance and submitting reports.; Entity that can use the checklist as a reference for submissions.

Regulatory Context

Attributes

2
Expiration date

should be based on appropriate supportive stability data

substantial equivalence

The standard for clearing a 510(k) device relative to a predicate.

Identified Hazards

Hazards

2
Migration of unreacted material

Safety concern for devices that polymerize in situ.

Bovine Spongiform Encephalopathy

Causative agent requiring inactivation controls

Related CFR Sections (3)

Related Warning Letters (2)

  • Medical Devices/Adulterated/Quality System Regulation (QSR)

    iRhythm Technologies, Inc.

    2023-06-06
  • Medical Device/Adulterated/Misbranded/Lacks PMA and/or 510(k)

    Tenderneeds Fertility LLC

    2020-04-21

See Also (8)