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CPG Sec. 446.100 Regulatory Action Regarding Approved New Drugs and Antibiotic Drug Products Subjected to Additional Processing or other Manipulations

FinalCenter for Drug Evaluation and Research01/18/1991

Description

FDA is issuing this policy guide to describe the circumstances in which the agency may initiate regulatory action regarding the marketing of approved new drugs and antibiotics that have been subjected to further processing or other manipulation, such as repacking, that is not covered by an approval under sections 505 or 507. (See U.S. v. Baxter Healthcare Corp., et al., CCH 38,166 Docket Nos. 89-2087/8 (7th Cir. May, 1990)).

Scope & Applicability

Product Classes

3
Sterile Drug Product

Products requiring sterility assurance and ISO 5 environments; Products requiring sterility testing and specific environmental controls.; products requiring sterility and BUD labeling; products requiring sterility and stability testing; Products requiring sterility or container-closure integrity tests

Antibiotic Drug Product

Regulatory Action Regarding Antibiotic Drug Products

New Drug

Subject of the benefit-risk assessment guidance

Stakeholders

2
Manufacturer

Entity responsible for submitting NDINs

Pharmacist

Allowed value for reporter qualification

Identified Hazards

Hazards

1
Microbiological Contamination

Environmental factors affecting biological products

Related CFR Sections (1)

See Also (8)

CPG Sec. 446.100 Regulatory Action Regarding Approved New Drugs and Antibiotic Drug Products Subjected to Additional Processing or other Manipulations | Guideline Explorer | BioRegHub