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Use of Real-World Evidence to Support Regulatory Decision-Making for Medical Devices: Guidance for Industry and Food and Drug Administration Staff

FinalCenter for Devices and Radiological Health Center for Biologics Evaluation and Research12/18/2025

Scope & Applicability

Product Classes

5
Medical Device

FDA intends to assess device cybersecurity based on a number of factors; demonstrate or maintain its safety and effectiveness; ensuring cybersecurity has become essential to FDA’s ability to protect the public health; Cyber-resiliency capabilities for medical devices

Class II device

Device classification mentioned regarding novel sterilization methods

Medical Devices

Medical devices intended for human use; Approved or cleared medical devices

Class I Device

Low risk medical devices

Artificial Intelligence-enabled medical device

Devices requiring training and monitoring throughout TPLC

Stakeholders

2
Sponsor

Entity responsible for submitting applications under section 524B

Manufacturer

Entity responsible for submitting NDINs

Regulatory Context

Attributes

7
Relevance

relevance includes the availability of data for key study variables

Statistical Power

adequate statistical power and accounting for planned analyses

Traceability

Ability to track the history of data

Data Provenance

Importance of data extraction and curation history

Sample Size

statistically justified calculation required in the plan

Reliability

reliability includes accuracy, completeness, and traceability

Significant Risk Device

Classification of metallic and calcium phosphate coated orthopedic devices

Related CFR Sections (4)

Related Warning Letters (10)

  • CGMP/QSR/Medical Devices/Adulterated/Misbranded

    Royal Philips

    2025-10-28
  • Medical Device Reporting/Misbranded

    Insung Medical Co. Ltd.

    2025-09-30
  • Clinical Investigator

    Shirish M. Gadgeel, M.D.

    2025-09-09
  • Clinical Investigator

    Mark J. Savant, M.D

    2025-07-15
  • Medical Device Reporting/Misbranded

    Insightra Medical Inc.

    2025-07-08
  • CGMP/QSR/Medical Devices/Adulterated

    Aju Pharm Co., Ltd.

    2025-06-24
  • CGMP/QSR/Medical Devices/Adulterated

    DFI Co., Ltd.

    2025-06-03
  • Bioresearch Monitoring Program/Institutional Review Board (IRB)

    United Health Products, Inc.

    2025-05-20
  • CGMP/QSR/Medical Devices/Adulterated

    EpiCare Acquisitions, LLC

    2025-04-08
  • Clinical Investigator

    Americo F. Padilla, M.D.

    2025-03-25

See Also (8)