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Uniform Contraceptive Labeling - Guidance for Industry

FinalCenter for Devices and Radiological Health07/22/1998

Description

U.S. Department Of Health and Human ServicesFood and Drug AdministrationCenter for Devices and Radiological Health

Key Topics

Terms and concepts identified from this document

Scope & Applicability

Product Classes

10
Hormonal Methods

Implant, Hormone Shot, Combined Pill, and Minipill

Intrauterine Devices

Copper T and Progesterone T methods

Vaginal Sponge

Barrier method containing spermicide

Male Latex Condom

Information for a Male Latex Condom 510(k) Submission

Latex Condom

use a latex condom to help reduce the risk of transmission of many STDs

Natural Skin Condom

labeling for natural skin condoms

Tubal Occlusion Device

contraceptive devices including tubal occlusion devices (TODS)

Intrauterine Device

contraceptive devices including intrauterine devices (IUDs)

Cervical Cap

contraceptive devices including cervical caps; claims for STD protection afforded by cervical caps

Diaphragm

contraceptive devices including diaphragms; clinical studies of diaphragms and vaginal spermicides regarding STD protection

Stakeholders

1
Manufacturer

Entity responsible for submitting NDINs

Regulatory Context

Regulatory Activities

2
PMA supplement

Required for changes affecting safety and effectiveness.; Submission for modifications to an approved PMA

510(k)

Premarket notification submission type

Document Types

4
Uniform Contraceptive Effectiveness Labeling

Memorandum on Uniform Contraceptive Effectiveness Labeling

Package Insert

Labeling information including dosage, administration, and safety sections

Professional Labeling

Cornerstone of risk management efforts for prescription drugs

Consumer Labeling

uniform approach to this type of labeling information for the consumer

Attributes

4
Lowest Expected Rate of Pregnancy

method was always used correctly with every act of sexual intercourse but failed anyway

Typical Use Rate of Pregnancy

estimates of the percent of women likely to become pregnant while using a particular contraceptive method

Contraceptive Efficacy

inclusion of a contraceptive efficacy table in the labeling

Pregnancy Rate

table with the pregnancy rates associated with all methods

Technical Details

Substances

5
Progesterone

Active component in Progesterone T IUD

Copper

Essential trace element in both animals and humans.

Progestin

COCs usually contain two synthetic steroid hormones, a progestin and an estrogen.; Hormonal component of COCs

Estrogen

COCs usually contain two synthetic steroid hormones, a progestin and an estrogen.

Vaginal Spermicide

clinical studies of diaphragms and vaginal spermicides

Clinical Concepts

10
STD

protection from a few STDs

Syphilis

Treponema pallidum infection

Hepatitis B

blood-borne pathogen risk for blood-contaminated devices

Gonorrhea

Infection requiring a 3-month deferral; Infection requiring 3-month deferral after treatment

Genital Warts

transmission of STDs including genital warts

Genital Herpes

transmission of STDs including genital herpes

Chlamydia

transmission of STDs including chlamydia

AIDS

Acquired Immunodeficiency Syndrome

HIV Infection

Comorbidity that should not exclude participants from clinical trials

Sexually Transmitted Disease

protection from sexually transmitted diseases (STDs)

Standards & References

External Standards

1
Contraceptive Technology (1997)

pregnancy rates based on data from Trussell, et al, from the 17th edition

Related MFDS Guidelines

Korean regulatory guidelines covering similar topics

See Also (8)

Uniform Contraceptive Labeling - Guidance for Industry | Guideline Explorer | BioRegHub