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Pediatric Information Incorporated Into Human Prescription Drug and Biological Products Labeling Good Review Practice

FinalCenter for Biologics Evaluation and Research Center for Drug Evaluation and Research03/28/2019

Description

This guidance is intended to assist applicants in determining the appropriate placement and content of pediatric information in human prescription drug and biological product labeling as described in the regulations for the content and format of labeling for human prescription drug and biological products.

Scope & Applicability

Product Classes

2
Human Prescription Drug

guidance applies to drugs regulated under section 505

Biological Product

Regulated under section 351(i) of the PHS Act; Virus, therapeutic serum, toxin, vaccine, or protein applicable to prevention or treatment; Alternative regulation category for products meeting device definition

Stakeholders

3
Applicants

Entities submitting supplements to BLAs

Health Care Providers

REMS program requires training be made available to all health care providers.

Sponsor

Entity responsible for submitting applications under section 524B

Regulatory Context

Attributes

3
Pediatric Age Groups

background on pediatric age groups

Contraindicated

Scenario where drug is prohibited for use in specific pediatric groups

Human equivalent dose

Clinically relevant term for summarizing animal data

Identified Hazards

Hazards

1
Safety Concern

Potential risk that may lead to removal of a device type from the pathway list.

Related CFR Sections (2)

See Also (8)

Pediatric Information Incorporated Into Human Prescription Drug and Biological Products Labeling Good Review Practice | Guideline Explorer | BioRegHub