Back to Explorer

FDA Institutional Review Board Inspections: Guidance For IRBs, Clinical Investigators, and Sponsors

FinalOffice of the Commissioner,Office of Clinical Policy and Programs,Office of Clinical Policy,Office of Good Clinical Practice01/01/2006

Scope & Applicability

Product Classes

2
Medical Device

FDA intends to assess device cybersecurity based on a number of factors; demonstrate or maintain its safety and effectiveness; ensuring cybersecurity has become essential to FDA’s ability to protect the public health; Cyber-resiliency capabilities for medical devices

Investigational Drug

drug or biological product not yet approved for marketing; Drugs used for treatment use under expanded access categories.; Drug used for treatment under expanded access; The product being provided through expanded access; Drugs provided under expanded access.

Stakeholders

2
IRB Chairperson

individual who may conduct expedited reviews

Clinical Investigator

Veterinarian responsible for selecting anesthetic regimens and conducting field studies

Regulatory Context

Attributes

1
Membership Roster

Examined to determine conformity to regulations

Related CFR Sections (2)

Related Warning Letters (10)

  • In Vivo Bioavailability-Bioequivalence Studies – Clinical

    Maria A. Carballosa, M.D.

    2025-12-23
  • Unapproved New Drug/Unlicensed Biological Product/Biologics License Application (BLA)

    Celularity, Inc

    2025-12-09
  • Sponsor/Investigator

    Verdure Sciences, Inc.

    2025-11-18
  • Clinical Investigator (Sponsor)

    Pamela K. Den Besten, DDS, MS

    2025-09-30
  • Clinical Investigator/Sponsor

    Ralph A. DeFronzo, M.D.

    2025-09-23
  • Clinical Investigator

    Shirish M. Gadgeel, M.D.

    2025-09-09
  • Clinical Investigator

    Mark J. Savant, M.D

    2025-07-15
  • Clinical Investigator

    Peter Michael, M.D.

    2025-07-01
  • Clinical Investigator (Sponsor)

    American Behavioral Research Institute, LLC

    2025-06-10
  • Bioresearch Monitoring Program

    Amy Lightner, MD

    2025-06-03

See Also (8)

FDA Institutional Review Board Inspections: Guidance For IRBs, Clinical Investigators, and Sponsors | Guideline Explorer | BioRegHub